The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.

The collagen binding protein Cnm contributes to oral 1 colonization and cariogenicity of Streptococcus mutans 2 OMZ 175 . 3 4

The collagen binding protein Cnm contributes to oral 1 colonization and cariogenicity of Streptococcus mutans 2 OMZ 175

4 James H. Miller, Alejandro Avilés-Reyes , Kathy Scott-Anne, Stacy Gregoire, Gene E. 5 Watson , Edith Sampson, Ann Progulske-Fox , Hyun Koo, William H. Bowen, José A. 6 Lemos 2 and Jacqueline Abranches 2# 7 8 Center for Oral Biology, Department of Microbiology and Immunology, Department of 9 Dentistry, Department of Environmental Medicine, University of Rochester School of Medicine 10 and Dent...

The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.

Streptococcus mutans is considered the primary etiologic agent of dental caries, a global health problem that affects 60 to 90% of the population, and a leading causative agent of infective endocarditis. It can be divided into four different serotypes (c, e, f, and k), with serotype c strains being the most common in the oral cavity. In this study, we demonstrate that in addition to OMZ175 and ...

Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study

Oral infectious diseases are epidemiologically associated with stroke. We previously showed that oral Streptococcus mutans with the cnm gene encoding a collagen-binding Cnm protein induced intracerebral hemorrhage (ICH) experimentally and was also associated with cerebral microbleeds (CMBs) in our population-based cohort study. We therefore investigated the roles of cnm-positive Streptococcus m...

Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment

Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy...